
At fictional Princeton Plainsboro Teaching Hospital in New Jersey, prickly genius Dr. Gregory House tackles health mysteries as would a medical Sherlock Holmes, all the while playing mind games with colleagues that include his best friend, oncologist James Wilson. House, an acerbic infectious disease specialist, solves medical puzzles with the help of a team of young diagnosticians. Flawless instincts and unconventional thinking help earn House great respect, despite his brutal honesty and antisocial tendencies.

House splits his time between treating a firefighter for uncontrollable shivering, giving Tritter a piece of his mind and handling his trial for forging prescriptions.

House returns to the hospital after a short stint in rehab; Cuddy comes to collect on the debt of perjuring herself for House; House encounters a patient who tests positive for an STD and says she was raped recently.

A 16-year-old patient has internal bleeding, but his Gypsy parents arrive and refuse all modern medical treatment.

A snowstorm leaves the ER short-staffed on Valentine's Day; House determines that Foreman's patient, who was injured in a car accident, has a rare condition that makes her completely insensitive to pain.