
After discovering that his late father has gone through most of the family fortune, Tod Stiles hits the title trans-America highway in his Corvette in search of adventure with friend Buz Murdock, a survivor of New York's mean streets. The two work odd jobs as they meet and interact with colorful characters and find themselves plunged into one situation after another, some of them romantic, some of them very dangerous. Later, Linc Case, a Vietnam war hero trying to find himself, takes over as Tod's travel companion.

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No one in the town of Amity will help a distraught girl (Susan Oliver) move her mother's body from a pauper's grave into the cemetery.
Tod and Buz go to work for a sand-and-gravel company in Cleveland, where they find a desperate love triangle that results in murder.
While he and Tod are working in a Montana copper mine, Buz falls in love with an actress (Anne Francis) dying from a rare blood disease.
The deaths of a rancher and his brother are blamed on a wild stallion with a killer reputation; guests Suzanne Pleshette, Claude Akins.